What is Nanoknife?

NanoKnife, also known as irreversible electroporation (IRE), is a medical technology used for treating certain types of cancer. It involves the use of electrical currents to create small pores or holes in cell membranes, causing the cells to undergo apoptosis (programmed cell death). This technique is typically used for tumors that are located near sensitive structures where traditional surgery may be risky or difficult.

Key points about NanoKnife:

  1. Mechanism: NanoKnife uses high-voltage electrical pulses delivered through electrodes to create pores in the cell membrane. These pores disrupt the cell’s internal balance, leading to cell death.
  2. Application: It is primarily used in the treatment of tumors that are difficult to treat with conventional surgery, radiation therapy, or chemotherapy. This includes tumors near blood vessels, nerves, or other critical structures.
  3. Advantages: Compared to traditional surgical methods, NanoKnife offers advantages such as preserving surrounding tissues, reducing the risk of collateral damage to nearby structures, and potentially offering quicker recovery times.
  4. Procedure: During the procedure, imaging techniques such as CT scans or MRI are used to precisely guide the electrodes to the tumor site. The electrical pulses are then delivered to the tumor, targeting the cancerous cells.
  5. Effectiveness: NanoKnife has shown promise in treating tumors in locations where preservation of function and quality of life are critical considerations. However, its effectiveness can vary depending on the type and location of the tumor.
  6. Research and Development: Research is ongoing to refine the technique and expand its applications. Clinical trials continue to evaluate its efficacy and safety for different types of cancer.

NanoKnife represents an innovative approach in the field of cancer treatment, offering a potential alternative or adjunct to traditional therapies for certain patients.

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